Abstract: According to the feature of GALILEO system, this paper focuses on the GALILEO/Strapdown Inertial Navigation System (SINS)pseudo range integrated navigation mode. This paper analyzes and builds GALILEO error equation, and the error mode and Kalman Filter equation of GALILEO/SINS pseudo range integrated navigation system is given. In order to verify the validity of the integrated navigation system designed, the covariance analysis method is used in virtual simulation to study the performance of the integrated navigation system. The results of virtual simulation show that the GALILEO/SINS pseudo range integrated navigation system can increase accuracy validity. Along with the improvement of GALILEO, this system will have a bright application prospect.