Abstract: Considering the validity of received data,a novel information infusion and localization technology was presented for wireless multisensor based on optimal geometrical topology theory. The optimal sensor-target geometrical localization and topological characteristics were studied with three types of measurements including range-only,time of arrival,bearing-only. The results show that the sensor-target geometrical topology with optimal localization performance can be implemented by analyzing the sensor-target geometrical characteristics. And the optimal geometrical topology is usually not exclusive. Considerable research foundation was provided for understanding the essence of localization,tracking and navigation for wireless multisensor by intrinsic geometrical topology.