Abstract: Research on fault diagnosis for spacecrafts is not only helpful to improve the safety and reliability of spacecrafts, but also to reduce their life cycle cost significantly. An Integrated Vehicle and Ground Fault Diagnosis System for space laboratory is described in detail. The system is consisted of Integrated Vehicle Fault Diagnosis System (IVFDS) with limited autonomous diagnosis capability, and Integrated Ground Fault Diagnosis System (IGFDS) including diagnosis system level fault and subsystem level fault. Model based reasoning (especially for multi signal model) is emphasized in this system. At the end of this paper, it is pointed on that some key techniques such as system modeling and component based diagnosis system, need to be studied in depth.