Abstract: This study systematically analyzes the engineering challenges associated with the application of organ chips in space and proposes corresponding solutions. It begins by reviewing the development of organ chip technology and its potential applications in space. The paper then examines the effects of the space environment, such as microgravity, radiation, and temperature fluctuations, on organ chips. The difficulties related to functional complexity, power consumption, size limitations, long-term stability, the need for standardization and validation are analyzed. Concluding the analysis, the study offers solutions that encompass surface coating and functional modifications, microenvironment control, automated monitoring and control systems, thereby providing an engineering framework for the deployment of organ chips in space.

Key words: organ-on-a-chip, space application, aerospace medicine, spacecraft