Abstract: Celestial navigation is one of the important methods of the deep space probe to realize autonomous navigation. Based on the orbit kinetic equation and the observation information to the orb, at the same time using the Kalman filter to accurately estimate the position and velocity of the spacecraft. But these angle measurements can't provide enough information to estimate the position of explorer with a high precision. This paper presents a new method of autonomous navigation which using both the celestial method and one-way Doppler measurement from ground stations based on information fusion. The simulation results show that the high precision of position determination can be obtained.