Abstract: In this paper,it is assumed that a series of errors are in consideration,which include the constant systematic error in optical measured data,the quadratic function systematic errors and refraction residual errors in MISTRAM system's positioning data and the linear errors and refraction residual errors in velocity data.Using splines to describe the trajectory of space vehicle,the author at first establishes a nonlinear regression model of trajectory parameters and systematic errors,and then gives a high precision nonlinear estimation method and algorithm of trajectory parameters and systematic errors.