Abstract:  Cislunar space is gradually becoming a focal area for human space exploration activities.Constructing a high-precision spatial-temporal reference and service is significant for planning and executing cislunar space missions.It is not only a systematic expansion of the spatial-temporal reference in the near-earth region，but also an important approach to enhance the guarantee capability of spatial-temporal information in cislunar space.With the development of GNSS，the infrastructure of spatial-temporal reference in the nearearth region is relatively comprehensive.The navigation system in the lunar region is similar to that of the near-earth region，and various solutions have been proposed.However，cislunar space also includes areas beyond the earth and the moon.Factors such as large airspace and particularity of dynamics should be adequately considered when the spatial-temporal reference is constructed，which can provide spatial-temporal information service with high benefits and connect the spatial-temporal reference of the earth and the moon organically.In this article，the spatial-temporal reference framework in cislunar space was designed based on the current demand of development.With characteristics of cislunar space beyond the earth and the moon considered，the scheme for constructing，tracing and transferring of the space-based earth-moon libration point spatial-temporal reference was researched and proposed.This scheme is anticipated to deliver a spatial-temporal information service with high accuracy and benefits，offering valuable reference for integrative construction and development of spatial-temporal reference in cislunar space.

Key words: cislunar space, libration point, space-based, spatial-temporal reference, navigation